AUTHOR=Liu Yin , Zhang Xi , Xu Hui-Fang , Shi Ji-Hai , Zhao Yu-Qian , Du Ling-Bin , Liu Yun-Yong , Wang Wen-Jun , Cao He-Lu , Ma Li , Huang Juan-Xiu , Cao Ji , Li Li , Fan Yan-Ping , Gu Xiao-Fen , Feng Chang-Yan , Zhu Qian , Wang Xiao-Hui , Du Jing-Chang , Zhang Jian-Gong , Zhang Shao-Kai , Qiao You-Lin
TITLE=Real-World Utilization, Barriers, and Factors Associated With the Targeted Treatment of Metastatic Colorectal Cancer Patients in China: A Multi-Center, Hospital-Based Survey Study
JOURNAL=International Journal of Public Health
VOLUME=68
YEAR=2023
URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2023.1606091
DOI=10.3389/ijph.2023.1606091
ISSN=1661-8564
ABSTRACT=Objectives: To explore the utilization, barriers, and factors associated with the targeted treatment of Chinese metastatic colorectal cancer (mCRC) patients.
Methods: A total of 1,688 mCRC patients from 19 hospitals in 14 cities were enrolled from March 2020 to March 2021 using stratified, multistage cluster sampling. The use of targeted therapy and any barriers patients experienced were collected. Logistic regression analyses were conducted to identify the factors associated with initiating targeted treatment.
Results: About 51.6% of the patients initiated targeted therapy, of whom 44.5%, 20.2%, and 35.2% started first-, second-, and third-line treatment, respectively. The most reported barriers were high medical costs and a lack of belief in the efficacy of targeted therapy. Patients treated in the general hospital, diagnosed at an older age, less educated, and who had a lower family income, no medical insurance, poor health-related quality of life, metastasis outside the liver/lung or systemic metastasis, a shorter duration of mCRC were less likely to initiate targeted therapy.
Conclusion: Reduced medical costs and interventional education to improve public awareness could facilitate the use of targeted treatment for mCRC.