AUTHOR=Dong Yinqiao , Wang Zhiqiang , Wang Suping , Chang Ruijie , Liu Yujie , Wang Rongxi , Chen Hui , Liu Shangbin , Qian Changlin , Cai Yong , Hu Fan 

TITLE=Gender-Specific and U-Shaped Relationship Between Serum Uric Acid and All-Cause Mortality Among Chinese Older Adults: A National Population-Based Longitudinal Study

JOURNAL=International Journal of Public Health

VOLUME=68

YEAR=2023

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2023.1605934

DOI=10.3389/ijph.2023.1605934

ISSN=1661-8564

ABSTRACT=<p><bold>Objectives:</bold> This study aimed to prospectively investigate gender-specific relationship between hyperuricemia and all-cause mortality among Chinese older adults.</p><p><bold>Methods:</bold> The study was based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2008–2018, a prospective nationwide cohort of older adults in China. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs for all-cause mortality. Restricted cubic splines (RCS) were conducted to explore the dose-response relationship between SUA levels and all-cause mortality.</p><p><bold>Results:</bold> For older women, compared to the participants in the third quartile of SUA level, those in the highest quartile of SUA was associated with significantly higher risk of all-cause mortality in the fully adjusted model (HR: 1.41, 95% CI: 1.03–1.92). No significant associations between SUA levels and all-cause mortality were observed in older men. The present study further found a U-shaped non-linear relationship between SUA levels and all-cause mortality in both sexes of older population (P for non-linear &lt;0.05).</p><p><bold>Conclusions:</bold> This study provided prospective epidemiological evidence for the predictive role of SUA on all-cause mortality among the Chinese aging population over 10 years of follow-up, while revealing considerable gender-related differences.</p>