AUTHOR=Wang Suixiang , Liu Shan , Nie Zhiqiang , Li Yexin , Li Ke , Liang Huanzhu , Chen Qian , Wen Lin , Xu Huan , Liang Boheng , Qin Pengzhe , Jing Chunxia 

TITLE=Temporal Trends in the Incidence and Mortality of Major Reproductive-Related Cancers in Women in Guangzhou From 2010 to 2020: A Joinpoint and Age-Period-Cohort Study

JOURNAL=International Journal of Public Health

VOLUME=68

YEAR=2023

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2023.1605300

DOI=10.3389/ijph.2023.1605300

ISSN=1661-8564

ABSTRACT=<p><bold>Objective:</bold> To understand the temporal trends of cancer incidence and mortality in women in Guangzhou during the past 11 years and provide clues for future research.</p><p><bold>Methods:</bold> Data were obtained from the Guangzhou Cancer and Death Registry. Average annual percentage changes (AAPCs) in age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were obtained by joinpoint regression. The age-period-cohort (APC) model was generated to quantify the effects of age, period, and cohort.</p><p><bold>Results:</bold> The ASIRs for cervical (AAPC = −4.3%) and ovarian (AAPC = −3.2%) cancers showed a downward trend during 2010–2020, and that for uterine cancer showed an upward trend. The ASMRs of breast (APC = 5.0%) and cervical (APC = 8.8%) cancers increased. The APC model highlights different age, period, and birth cohort effects depending on the cancer site.</p><p><bold>Conclusion:</bold> The ASIRs for cervical and ovarian cancers among women in Guangzhou showed a decreasing trend during the period. The APC model showed mortality for 4 cancers increased with age. Incidence and mortality decreased with increasing birth cohort. Annual reproductive cancer screening is recommended for women of appropriate age to reduce the disease burden.</p>