AUTHOR=Zuo Lei , Chen Xia , Liu Mingliang , Chen Li , Xu Wenbin , Chen Haiyan , Dong Shan , Wei Yuan , Li Liangming , Peng Shuang , Hao Guang 

TITLE=Road Traffic Noise, Obesity, and the Risk of Incident Type 2 Diabetes: A Cohort Study in UK Biobank

JOURNAL=International Journal of Public Health

VOLUME=67

YEAR=2022

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2022.1605256

DOI=10.3389/ijph.2022.1605256

ISSN=1661-8564

ABSTRACT=<p><bold>Objectives:</bold> To assess the association of road traffic noise exposure with Type 2 Diabetes (T2D) risk, and to explore the potential moderation effect of obesity.</p><p><bold>Methods:</bold> A total of 305,969 participants from the UK Biobank Cohort - an open access cohort of 500,000 participants recruited in the United Kingdom (UK) between 2006 and 2010 - were included in the study. A Cox proportional hazard model was fitted to assess the association between road traffic noise exposure and T2D.</p><p><bold>Results:</bold> A total of 19,303 participants were diagnosed with T2D during the 11.9-year median follow-up period. For every 10 dB increase in road traffic noise, there was a 4% increase in T2D risk (HR = 1.04, 95%CI: 1.01, 1.07). Besides, a significant positive interaction was observed between obesity and road traffic noise (<italic>P</italic> interaction &lt;0.001) for the risk of T2D. The association of road traffic noise with T2D was stronger in overweight and obese participants (HR = 1.04, 95% CI: 1.01–1.08), but not significant among lean ones (HR = 0.96, 95% CI: 0.86–1.07).</p><p><bold>Conclusion:</bold> Our study observed a longitudinal association of road traffic noise exposure with T2D risk, which was stronger among overweight and obese individuals than the lean ones.</p>