AUTHOR=Hu Zhigang , Tian Yufeng , Song Xinyu , Hu Ke , Yang Ailan 

TITLE=Associations Between Incident Asthma With Comorbidity Profiles, Night Sleep Duration, and Napping Duration Trajectories: A 7-Year Prospective Study

JOURNAL=International Journal of Public Health

VOLUME=67

YEAR=2022

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2022.1604939

DOI=10.3389/ijph.2022.1604939

ISSN=1661-8564

ABSTRACT=<p><bold>Objectives:</bold> We aim to determine whether comorbidity profiles, night sleep duration, and napping duration trajectories were associated with incident asthma in Chinese adults.</p><p><bold>Methods:</bold> A total of 7,655 community-dwelling individuals were included in this study. Latent class/profile analysis(LCA/LPA) identified comorbidity profiles, night sleep duration, and napping duration trajectories. A generalized additive model with binomial regression assessed the associations between incident asthma with sleep trajectories.</p><p><bold>Results:</bold> During a 7-year follow-up period, 205 individuals were newly diagnosed with asthma. LPA identified four trajectories of night sleep duration: dominant short (<italic>n</italic> = 2,480), dominant healthy-long (<italic>n</italic> = 1,405), long decreasing (<italic>n</italic> = 1875), and short increasing (<italic>n</italic> = 1895). We also found three trajectories of napping duration: short increasing (<italic>n</italic> = 3,746), stable normal (<italic>n</italic> = 1,379), and long decreasing (<italic>n</italic> = 2,530). We found three comorbidity profiles: dominant heart diseases or risks (<italic>n</italic> = 766), multiple disorders (<italic>n</italic> = 758), and minimal or least disorders (<italic>n</italic> = 6,131). Compared with dominant short night sleep duration, three other trajectories were associated with significantly decreasing incident asthma. Minimal or least disorders profile was associated with a significant reduction of new-onset asthma than two other comorbidity profiles in dominant short night sleep duration.</p><p><bold>Conclusion:</bold> Our findings suggested that a dominant short night sleep duration trajectory potentially increases incident asthma in Chinese adults.</p>